It seems there's something dangerous about the first Thursday of The Championships for seeded Spanish players.

On this day last year, Rafael Nadal was beaten by German Dustin Brown, and this time it was Garbine Muguruza who said goodbye to Wimbledon when she fell to Slovakia’s unseeded Jana Cepelova.

Later on Day 4, Muguruza was almost joined on the sidelines by No.3 seed Agnieszka Radwanska only for the Pole to survive three match points before scrambling past young Croat Ana Konjuh 9-7 in the decider.

Another big name did eventually follow Muguruza through the exit door, however, when Jiri Vesely outplayed No.8 seed Dominic Thiem in the dusk on No.1 Court.

There were mixed fortunes for the home-grown players. Andy Murray cruised into round three and was joined in the round of 32 by Dan Evans who’ll face Roger Federer on Friday.

In the ladies’ draw, British No.16 seed Johanna Konta lost in three sets to former finalist Eugenie Bouchard on Centre Court, and Heather Watson also went out – in three tight sets to Germany’s Annika Beck.

There were plenty more big names who failed to survive past the fourth day of the tournament – men’s seeds to fall on Thursday included No.13 seed David Ferrer, No.16 seed Gilles Simon, No.23 seed Ivo Karlovic, No.25 seed Viktor Troicki, No.26 seed Benoit Paire and No.30 seed Alexandr Dolgopolov.

Besides Muguruza, the ladies’ draw lost No.7 seed Belinda Bencic, No.15 seed Karolina Pliskova, No.17 seed Elina Svitolina, No.20 seed Sara Errani, No.22 seed Jelena Jankovic, No.30 seed Caroline Garcia, No.31 seed Kristina Mladenovic and No.32 seed Andrea Petkovic.

Day 4 in numbers

• Murray has reached at least the third round on every visit to The Championships – he is into the round of 32 for the 11^th time
• Murray has now played 57 matches at Wimbledon – the same number as Tim Henman and Rod Laver
• The world No.2 has now won 200 sets at Wimbledon, moving him into the top 20 on that leaderboard
• Cepelova recorded the third top-five win of her career – she also beat Serena Williams in 2014 and Simona Halep at Wimbledon in 2015
• Bernard Tomic chalked up his 150^th Tour-level victory
• Venus Williams reached the 12,000 Wimbledon points played milestone on Thursday, the most of all time 
• Five former Wimbledon junior champions were in action in the men’s draw – Nicolas Mahut, Jeremy Chardy, Donald Young, Grigor Dimitrov and Andrey Kuznetsov
• It was a 27^th Wimbledon win for Richard Gasquet – that takes him to 6^th on the list for most Wimbledon wins by a Frenchman (Jean Borotra leads on 55)
• Mahut scored his first win over a Spaniard at a Grand Slam when he got past Ferrer
• Evans’ win over Dolgopolov equals his best Grand Slam run – he also made the third round at the 2013 US Open
• Ivo Karlovic boomed down his 800^th Wimbledon ace during his surprise defeat to Lukas Lacko. Goran Ivanisevic is the all-time leader on 1,397