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Sam Querrey made sure of a permanent place in the Wimbledon history books with his shock humbling of No.1 seed Novak Djokovic on Saturday.
Here Wimbledon.com looks at other big upsets at the All England Club.
George Bastl beats Pete Sampras, second round 2002
At the changeovers, Sampras read a letter from his wife, the Hollywood actress Bridgette Wilson. "My husband, seven-times Wimbledon champion, Pete," it began, "remember this - you truly are the greatest player ever to pick up a racket." Unfortunately that note couldn't prevent Sampras from going down against Bastl, a 'lucky loser' from Switzerland with a triple-digit ranking. This was played on the No.2 Court, the old graveyard of champions; it was the biggest tombstone of all.
Jelena Dokic defeats Martina Hingis, first round 1999
Hingis was supposed to The Swiss Who Couldn't Miss. And then this happened, a defeat to a 16-year-old qualifier ranked outside the top 100. And Hingis, the No.1 seed that summer, didn't just lose, but lost heavily, gathering just two games in the most lop-sided of matches. One explanation was that this was Hingis' first Grand Slam match without her mother Melanie in attendance, with the player saying: "We decided to have a little bit of distance." The greatest gap, though, was between Hingis and Dokic.
Lori McNeil beats Steffi Graf, first round 1994
Graf's domination on the grass - she was on a run of three successive titles, or 21 unbroken victories, at the All England Club - was reset to zero against the American. Graf became the the first women's defending champion to lose in the first round. Still, this result hardly unsettled her in future years as she picked up the Venus Rosewater Dish for the next two summers - in 1995 and 1996 - and so ended her career with seven Wimbledon titles.
Peter Doohan beats Boris Becker, second round 1987
The men's singles champion at 17, and then the winner again at 18, Becker had a rough summer at 19. Still, Becker was about the only person at the All England Club that day to have retained his perspective - the Four Horsemen of the Apocalypse weren't about to come riding down the hill from Wimbledon Village and through the wrought-iron gates of the Club. "I lost a tennis match, it wasn't a war - nobody died out there," said Becker. His Australian opponent, meanwhile, became known as 'The Becker Wrecker'.
Sergiy Stakhovsky beats Roger Federer, second round 2013
This was Wild Wednesday at the All England Club. Or perhaps you prefer Wacky Wednesday or Wipeout Wednesday. It was Day 3 of The Championships and seeds were being scattered all over the grounds. But the greatest of all the surprises that day was Federer losing to Stakhovsky, an opponent ranked outside the top 100, in what was his earliest defeat at the majors for a decade.
Ivo Karlovic defeats Lleyton Hewitt, first round 2003
At nearly 7ft tall, Karlovic hardly been incognito in tennis before this match. But it's fair to say that a good number of spectators were not exactly au fait with the Croatian's talents - not least, his serve - before this encounter. When Hewitt took the first set, all was passing off as expected. But then the match turned, with Karlovic winning in four sets and Hewitt becoming the first men's defending champion in the Open era to lose in the opening round.
Lukas Rosol defeats Rafael Nadal, second round in 2012
Rosol entered a trance-like state on Centre Court, swinging away at his forehand until he had bumped this former champion from the draw. At the time, this appeared to be the greatest shock in the history of the All England Club. But it subsequently emerged that Nadal's knees had been causing him lots of pain.
